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Related Experiment Video

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FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions.

Shelin Adam¹, Patricia H Birch², Rachel R Coe¹

¹Department of Medical Genetics, University of British Columbia, Box 153, 4500 Oak Street, Vancouver, BC, V6H 3N1, Canada.

Journal of Genetic Counseling

|July 24, 2018

Summary

An online tool, DECIDE, effectively provided pre-test genetic counseling for genome-wide sequencing (GWS), matching traditional methods in patient knowledge. This digital approach enhances accessibility to genetic counseling services.

Keywords:

Decision aid Decisional support Genetic counseling Genomic testing decisions Patient knowledge Patient-empowerment

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Area of Science:

Genetics
Medical Informatics
Patient Education

Background:

Genome-wide sequencing (GWS) requires genetic counseling, but access is limited.
Developing accessible decision-support tools is crucial for clinical genetic services.

Purpose of the Study:

To assess the clinical utility of an interactive online decision-support tool, DECIDE, for pre-genome-wide sequencing (GWS) counseling.
To compare the effectiveness of DECIDE against standard genetic counseling in a non-inferiority trial.

Main Methods:

A non-inferiority trial involving 106 parents considering GWS for children with epilepsy.
Randomization to either DECIDE or conventional genetic counseling.
Measurement of parental knowledge, empowerment, and user opinions post-intervention.

Main Results:

Both DECIDE and conventional counseling significantly improved parental knowledge, with no significant difference between groups.
Parental empowerment showed a minimal increase (<2%) in both groups.
DECIDE was highly acceptable, with 81% recommending it and many finding it useful for decision-making.

Conclusions:

DECIDE is equivalent to traditional genetic counseling in conveying information prior to GWS.
The online tool effectively increases patient knowledge and is well-received, potentially extending genetic counseling resources.
DECIDE offers a viable solution to improve access to genetic counseling for genome-wide sequencing.