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Updated: Feb 7, 2026

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Double-Oxidative Dehydrogenative (DOD) [4 + 2]-Cyclization/Oxidative Aromatization Tandem Reaction of Glycine
Wei Jiang1, Yajun Wang1, Pengfei Niu1
1Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou , Gansu 730070 , China.
Abstract:
The double-oxidative dehydrogenative (DOD) cyclization represents one of the most straightforward and atom-economical methods for cyclic structure formation. A Cu(II)/DDQ/O2 system-catalyzed DOD [4 + 2]-annulation/oxidative aromatization tandem reaction of readily available glycine derivatives and alkylbenzenes was established. This approach facilitates rapid access to a broad scope of substituted quinoline-2-carboxylate derivatives, an important motif in drug discovery. The reaction could feasibly be applied to a 10 gram-scale synthesis.
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