Related Experiment Video

Updated: Feb 7, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

12.4K

Cystatin C as an index of acute cerebral infraction recurrence: one-year follow-up study

Xiaoyu Dong1, Jianfei Nao1

  • 1a Department of Neurology , Shengjing Hospital of China Medical University , Shenyang , Liaoning , PR China.

The International Journal of Neuroscience
|July 24, 2018
PubMed

Insights

Serum cystatin C is a key predictor of acute cerebral infarction (ACI) recurrence. Elevated levels are linked to higher recurrence risk and the large-artery atherosclerosis subtype.

Area of Science:

  • Neurology
  • Biochemistry
  • Cardiovascular Medicine

Background:

  • Cystatin C is implicated in acute cerebral infarction (ACI).
  • The precise relationship between serum cystatin C levels and ACI recurrence or specific ACI subtypes remains unclear.

Purpose of the Study:

  • To investigate the association between serum cystatin C levels and the recurrence of ACI over a one-year follow-up period.
  • To explore the correlation of serum cystatin C levels with different subtypes of ACI.

Main Methods:

  • A cohort of 532 ACI patients and 339 healthy controls were analyzed.
  • ACI patients underwent a one-year follow-up to document clinical and biochemical characteristics, including recurrence events.

Main Results:

  • Of 477 patients completing follow-up, 64 experienced ACI recurrence.
  • Serum cystatin C levels were significantly higher in ACI patients compared to controls (p < .001).
  • Independent risk factors for ACI recurrence included hypertension, diabetes, coronary heart disease, and elevated cystatin C (p = .003, OR = 2.87).
  • Higher serum cystatin C levels correlated with increased ACI recurrence risk.
  • The large-artery atherosclerosis (LAA) subtype showed the highest cystatin C levels in both ACI and recurrent ACI groups.

Conclusions:

  • Serum cystatin C serves as an independent predictive biomarker for ACI recurrence.
  • Elevated cystatin C levels are strongly associated with the LAA subtype of ACI and ACI recurrence.
Abstract

Keywords:
Cystatin Cacute cerebral infarctionrenal insufficiency

More Related Videos

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.8K
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats06:39

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Published on: October 17, 2018

6.9K

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
432
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
285
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
343
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.5K
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
4.3K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.3K