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Updated: Feb 7, 2026

Bioluminescence-Based Tumor Quantification Method for Monitoring Tumor Progression and Treatment Effects in Mouse Lymphoma Models
Published on: July 7, 2016
Monitoring response in lymphomas: qualitative, quantitative, or what else?
Alberto Biggi1, Fabrizio Bergesio2, Stephane Chauvie2
1a Department of Nuclear Medicine , Santa Croce e Carle Hospital , Cuneo , Italy.
Abstract:
The Deauville criteria (DC) shall always be used to report interim and final PET and to assign metabolic response categories in FDG-avid lymphoma. A recent review article supports the role of quantitative extension of the DC to improve response assessment in lymphoma. We analyze different quantitative approach, to help physician to better distinguish what has to be done in every day clinical practice respect to what represent interesting insights and ongoing research. Respect to DC, all the proposed quantitative approaches obtained in retrospective studies, requires mature follow-up and a validation in independent cohorts of lymphoma patients. Moreover, the sensitivity of the system, not the adequate specificity of the tracer and the biology of the disease together with the DC, influence the accuracy of PET/CT. In conclusions, in current clinical practice, the DC, validated in a large cohort of lymphoma patients, represent the standard criteria for PET interpretation.
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