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Updated: Feb 7, 2026

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
Published on: March 3, 2015
PCA meets RG
Serena Bradde1, William Bialek1,2
1Initiative for the Theoretical Sciences, The Graduate Center, City University of New York, 365 Fifth Ave., New York, New York 10016.
Abstract:
A system with many degrees of freedom can be characterized by a covariance matrix; principal components analysis (PCA) focuses on the eigenvalues of this matrix, hoping to find a lower dimensional description. But when the spectrum is nearly continuous, any distinction between components that we keep and those that we ignore becomes arbitrary; it then is natural to ask what happens as we vary this arbitrary cutoff. We argue that this problem is analogous to the momentum shell renormalization group (RG). Following this analogy, we can define relevant and irrelevant operators, where the role of dimensionality is played by properties of the eigenvalue density. These results also suggest an approach to the analysis of real data. As an example, we study neural activity in the vertebrate retina as it responds to naturalistic movies, and find evidence of behavior controlled by a nontrivial fixed point. Applied to financial data, our analysis separates modes dominated by sampling noise from a smaller but still macroscopic number of modes described by a non-Gaussian distribution.
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