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A case report of toxic epidermal necrolysis associated with AZD-9291

Jie Wang1, XianYe Cheng1, Yan Lu1

  • 1Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, The People's Republic of China, bingrong.2002@163.com.

Drug Design, Development and Therapy
|July 24, 2018
PubMed

Insights

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) can cause skin toxicity. A rare case of toxic epidermal necrolysis occurred in a patient treated with the newer EGFR-TKI, AZD-9291.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are crucial in treating metastatic non-small cell lung cancer.
  • Common side effects include acneiform rash, skin fissures, xerosis, and paronychia.
  • Severe skin reactions like necrosis and exfoliation are rare.

Observation:

  • AZD-9291 is a newer generation EGFR-TKI, noted for improved efficacy and tolerability, especially for EGFR T790M mutations.
  • A 51-year-old male patient was treated with AZD-9291.
  • The patient developed extensive skin necrosis.

Findings:

  • The patient was diagnosed with toxic epidermal necrolysis.
  • This severe adverse event occurred following AZD-9291 administration.
  • This case highlights a rare but severe dermatological toxicity associated with AZD-9291.

Implications:

  • Clinicians should be vigilant for severe skin reactions in patients receiving AZD-9291.
  • Further investigation into the mechanisms of AZD-9291-induced toxic epidermal necrolysis is warranted.
  • This case underscores the importance of monitoring for rare adverse events even with newer targeted therapies.
Keywords:
AZD-9291EGFR-TKIsNSCLCTENosimertinib

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