Related Experiment Video
Updated: Feb 7, 2026

Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Brain Tumours: Rise in Glioblastoma Multiforme Incidence in England 1995-2015 Suggests an Adverse Environmental or
Alasdair Philips1,2, Denis L Henshaw1,3, Graham Lamburn2
1Children with Cancer UK, 51 Great Ormond Street, London, WC1N 3JQ, UK.
Objective:
To investigate detailed trends in malignant brain tumour incidence over a recent time period.
Methods:
UK Office of National Statistics (ONS) data covering 81,135 ICD10 C71 brain tumours diagnosed in England (1995-2015) were used to calculate incidence rates (ASR) per 100k person-years, age-standardised to the European Standard Population (ESP-2013).
Results:
We report a sustained and highly statistically significant ASR rise in glioblastoma multiforme (GBM) across all ages. The ASR for GBM more than doubled from 2.4 to 5.0, with annual case numbers rising from 983 to 2531. Overall, this rise is mostly hidden in the overall data by a reduced incidence of lower-grade tumours.
Conclusions:
The rise is of importance for clinical resources and brain tumour aetiology. The rise cannot be fully accounted for by promotion of lower-grade tumours, random chance or improvement in diagnostic techniques as it affects specific areas of the brain and only one type of brain tumour. Despite the large variation in case numbers by age, the percentage rise is similar across the age groups, which suggests widespread environmental or lifestyle factors may be responsible. This article reports incidence data trends and does not provide additional evidence for the role of any particular risk factor.
More Related Videos
10:52Stereotactic Intracranial Implantation and In vivo Bioluminescent Imaging of Tumor Xenografts in a Mouse Model System of Glioblastoma Multiforme
Published on: September 25, 2012
09:02Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
Published on: September 27, 2024
Related Concept Videos
Lifestyle Factors and Health
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Introduction to Stress and Lifestyle
Rise of Liquid in a Capillary Tube
Transcription Factors
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...