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Propranolol and breast cancer-a work in progress

Pan Pantziarka1,2, Brad A Bryan3, Sergio Crispino1

  • 1Anticancer Fund, Brussels, 1853 Strombeek-Bever, Belgium.

Ecancermedicalscience
|July 24, 2018
PubMed

Insights

The common drug propranolol shows promise as an anti-cancer treatment, especially for breast cancer. Its ability to stop cancer spread (metastasis) suggests potential use around surgery.

Area of Science:

  • Oncology
  • Pharmacology
  • Translational Medicine

Background:

  • Propranolol, a non-selective beta-blocker, is being investigated for novel anti-cancer applications.
  • Emerging evidence, including human data, highlights its potential mechanisms of action in breast cancer.

Discussion:

  • Recent studies indicate propranolol possesses anti-metastatic properties.
  • These findings support further clinical investigation into propranolol's efficacy against cancer spread.

Key Insights:

  • Propranolol demonstrates anti-metastatic activity relevant to breast cancer.
  • Multiple mechanisms of action are suggested by current research.

Outlook:

  • Clinical investigation of propranolol as a perioperative therapy for breast cancer is warranted.
  • Further research may establish propranolol as a repurposed anti-cancer agent.
Keywords:
beta blockerbreast cancerdrug repurposingperioperative therapiespropranolol

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