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Author Spotlight: Advancing Structural and Biochemical Studies of Proteins Through Thermal Shift Assays
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Emerging Utility of Fluorosulfate Chemical Probes
1Jnana Therapeutics, 50 Northern Avenue, Boston, Massachusetts 02210, United States.
ACS Medicinal Chemistry Letters
|July 24, 2018
Abstract:
Aryl fluorosulfates are finding widespread utility in chemical biology and medicinal chemistry. The context-dependent engagement of tyrosine, lysine, serine, and histidine amino acid residues in functional protein sites has enabled chemogenomic and chemoproteomic techniques that demonstrate considerable promise for drug discovery and biomedical research.
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