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Updated: Feb 7, 2026

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis
Published on: September 2, 2021
Bone mineral density and microarchitecture linkages with micro- and macro-vascular impairments at the hand in
Lucie Atlan1, Nada Ibrahim-Nasser2,3, Antoine Valery4
1Department of Rheumatology, University Hospital of Tours, Tours, France.
Objective:
To investigate the link between bone alteration and micro- and macro-vascular disease in patients with systemic sclerosis (SSc).
Results:
33 SSc patients were included. In univariate analysis, low values of cortical vBMD were significantly associated with a low DBI at the 2nd finger (p = 0.004) and at the 4th (p = 0.002) and with severe capillaroscopic score (p = 0.008). In multivariate analyses, low cortical vBMD was associated with a low DBI at the 4th finger, age and severe capillaroscopic score (adjusted R2 = 0.58; p = < 0.001). Low cortical thickness was associated with a low DBI at the 4th finger, severe capillaroscopic score and age (adjusted R2 = 0.49, p = < 0.001).
Conclusion:
Our study findings showed an association between micro- and macro-vessel damage and altered microarchitectural indices at the radius in SSc.
Methods:
We performed a pilot study in female patients with SSc. Microvascular disease was assessed by the capillaroscopic score of Cutolo. Macrovascular involvement was measured by digito-brachial pressure index (DBI) on laser-Doppler at the 2nd and 4th finger. Volumetric bone mineral density (vBMD) and bone microarchitecture involvement were analysed by High-Resolution peripheral Quantitative Computed Tomography (HRpQCT) at the distal radius.
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