Related Experiment Video

Updated: Feb 7, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.2K

Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and

Rong Yuan1,2, Qiqi Xin2, Weili Shi2

  • 1Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Cardiovascular Therapeutics
|July 24, 2018
PubMed

Insights

Vascular endothelial growth factor (VEGF) gene therapy shows promise in reducing serious cardiac events for coronary artery disease (CAD) patients. While safe and effective, particularly with adenoviral vectors, it did not impact mortality or angina scores.

Area of Science:

  • Cardiovascular Medicine
  • Gene Therapy
  • Regenerative Medicine

Background:

  • Coronary artery disease (CAD) poses a significant global health burden.
  • The efficacy of vascular endothelial growth factor (VEGF) gene transfer for improving myocardial ischemia and treating CAD remains unclear.
  • Proangiogenesis mechanisms are central to exploring novel therapeutic strategies for CAD.

Purpose of the Study:

  • To systematically review and meta-analyze randomized controlled trials (RCTs) comparing VEGF gene therapy with standard treatments in CAD patients.
  • To assess the safety and efficacy of VEGF gene therapy in improving cardiac outcomes.
  • To evaluate the impact of VEGF gene therapy on mortality, serious cardiac events, left ventricular ejection fraction (LVEF), and angina.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane databases up to May 2018.
  • Inclusion of RCTs comparing VEGF gene therapy and standard care for CAD.
  • Meta-analysis using fixed and random effects models with primary outcomes of mortality and serious cardiac events, and secondary outcomes including LVEF and angina.

Main Results:

  • 14 RCTs involving 524 studies were included in the meta-analysis.
  • VEGF gene therapy significantly decreased the risk of serious cardiac events (RR: 0.56; 95% CI: 0.37, 0.84; P=0.005).
  • A slight improvement in follow-up LVEF (WMD: 1.95; 95% CI: 1.28, 2.62) was observed; adenoviral vectors showed enhanced benefits for cardiac events and LVEF, but mortality and angina scores were unchanged.

Conclusions:

  • VEGF gene therapy demonstrates safety and efficacy in reducing serious cardiac events in CAD patients.
  • Adenoviral vector-based VEGF gene therapy offers greater potential benefits.
  • Further research is warranted to fully elucidate the therapeutic potential of VEGF gene therapy in cardiovascular disease.
Abstract

Keywords:
angina pectorisangiogenesis inducing agentscoronary artery diseasegenetic therapymyocardial ischemiavascular endothelial growth factor

More Related Videos

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium10:18

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

Published on: May 6, 2018

9.7K
Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

19.6K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
500
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
289
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
399
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
703