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Published on: August 19, 2020
[Disorders of sexual differentiation in children: a critical look at open questions (part I)]
N D Shiryaev1,2,3,4,5, I M Kagantsov1,2,3,4,5, V V Sizonov1,2,3,4,5
1Northern State Medical University of Minzdrav of Russia, Arkhangelsk, Russia.
Abstract:
Management of children with disorders of sexual differentiation (DSD) continues to cause questions and receive criticism. This review discusses some contradictions concerning the newly proposed terminology, nomenclature, and classification. Congenital adrenal hyperplasia (CAH) is the most common cause of DSD, and its management also remains controversial. Therefore, in this part of the article, we critically analyze available literature on gender identity, the need and timing of surgery in children with DSD and 46, XX karyotype.
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