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Short-term propofol anaesthesia down-regulates clock genes expression in the master clock.

Nawfel Ben-Hamouda1,2, Vincent-Joseph Poirel1, Garance Dispersyn1,3

  • 1a Institut des neurosciences cellulaires et integratives, Neurobiology of Rhythms, CNRS (UPR3212) , Université de Strasbourg , Strasbourg , France.

Chronobiology International
|July 24, 2018
PubMed
Summary

Propofol anesthesia transiently reduces Per1 and Per2 gene expression in the brain's master clock, the suprachiasmatic nuclei (SCN). This finding may explain post-anesthesia "jet-lag-like" symptoms.

Keywords:
AnesthesiaCircadian rhythmsClock genesPropofolSuprachiasmatic nuclei

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