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Long-term recurrent bleeding risk after endoscopic therapy for definitive colonic diverticular bleeding: band
Naoyoshi Nagata1, Naoki Ishii2, Mitsuru Kaise3
1Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo, Japan.
Insights
Endoscopic band ligation shows a lower 1-year recurrent bleeding risk for colonic diverticular bleeding (CDB) compared to clipping. This suggests band ligation offers better long-term outcomes for managing CDB.
Area of Science:
- Gastroenterology
- Endoscopic interventions
- Gastrointestinal bleeding
Background:
- Limited prospective studies evaluate long-term outcomes of endoscopic therapy for colonic diverticular bleeding (CDB).
- Recurrent bleeding risk after endoscopic treatment for CDB requires further elucidation.
Purpose of the Study:
- To compare the 1-year recurrent bleeding risk of endoscopic band ligation versus clipping for definitive CDB.
- To evaluate long-term outcomes of endoscopic therapies for CDB based on stigmata of recent hemorrhage (SRH).
Main Methods:
- Prospective enrollment of patients hospitalized for acute lower GI bleeding.
- High-resolution colonoscopy with water-jet visualization for SRH.
- First-line treatment using endoscopic band ligation or clipping, followed by prospective follow-up.
Main Results:
- 1-year recurrent bleeding probability was significantly lower with band ligation (11.5%) versus clipping (37.0%).
- No statistical difference in baseline characteristics or follow-up duration between groups.
- Left colon location was an independent predictor for recurrent bleeding in the ligation group.
Conclusions:
- Endoscopic band ligation demonstrates superior long-term outcomes compared to clipping for definitive CDB treatment.
- Band ligation may be more effective due to complete diverticulum elimination, reducing recurrence.
- CDB recurrence can occur at the same diverticulum short-term or different diverticula long-term.
Background And Aims:
Very few prospective studies with over 100 samples have evaluated the long-term outcomes of endoscopic therapy for colonic diverticular bleeding (CDB). This study sought to elucidate the recurrent bleeding risk of endoscopic band ligation versus clipping for definitive CDB based on stigmata of recent hemorrhage (SRH).
Methods:
Patients emergently hospitalized for acute lower GI bleeding and examined by high-resolution colonoscopy were enrolled. Better visualization of SRH from a diverticulum was obtained using a water-jet device. Endoscopic band ligation or clipping was performed as first-line treatment, and patients were prospectively followed after discharge.
Results:
No statistical difference was found between the ligation (n = 61) and clipping (n = 47) groups in baseline characteristics or follow-up period. The probability of 1-year recurrent bleeding was 11.5% in the ligation group versus 37.0% in the clipping group (P = .018). No patients required surgery or experienced perforation. One patient in the ligation group experienced diverticulitis the next day. In patients with recurrent bleeding within 7 days, the recurrent bleeding site was the same diverticulum, and ulceration was found in the ligation group on repeat colonoscopy. In patients with recurrent bleeding after 2 months, repeat colonoscopy identified that the recurrent bleeding site was different, and scar formation was seen in the ligation group. The left side of the colon was an independent predictor for recurrent bleeding in the ligation group but not in the clipping group.
Conclusions:
Band ligation for definitive CDB has better outcomes than clipping during long-term follow-up after endoscopic therapy, probably because of complete elimination of the diverticulum. CDB can recur at the same diverticulum in the short term but at a different diverticulum in the long term.
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