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Related Experiment Videos

[Worldwide experience with enalapril].

R O Davies, J D Irvin, D K Kramsch

    Presse Medicale (Paris, France : 1983)
    |December 19, 1985
    PubMed
    Summary

    Enalapril demonstrates significant efficacy in treating essential hypertension, comparable to existing treatments. It offers improved tolerability and reduces metabolic side effects, making it a valuable option for managing high blood pressure.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Essential hypertension is a widespread condition requiring effective and well-tolerated treatments.
    • Current therapies include diuretics and beta-blockers, with varying efficacy and side effect profiles.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of enalapril in patients with essential hypertension.
    • To compare enalapril's effectiveness against diuretics and beta-blockers.
    • To assess enalapril's impact on metabolic side effects and its use in combination therapy.

    Main Methods:

    • Clinical trials involving patients with essential hypertension.
    • Comparative analysis of enalapril with diuretics and beta-blockers.
    • Assessment of patient response rates and adverse events.

    Main Results:

    • Enalapril achieved good to excellent responses in 54-66% of patients with essential hypertension.
    • Enalapril demonstrated comparable effectiveness to diuretics and beta-blockers.
    • Combination therapy with a diuretic resulted in near-universal response and sustained effect.
    • Enalapril reduced hypokalemia associated with hydrochlorothiazide.
    • Enalapril showed better tolerability than captopril, with fewer side effects like skin rashes and ageusia.

    Conclusions:

    • Enalapril is a highly effective treatment for essential hypertension, offering benefits over existing therapies.
    • Its favorable side effect profile and ability to mitigate metabolic disturbances enhance its therapeutic value.
    • Enalapril represents a significant advancement in antihypertensive pharmacotherapy.

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