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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

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Evidence-Based Valuation in Oncology:: Lessons Learned from a Case Study.

John J Doyle¹, Emily Hawryluk², Jeffrey Niemira³

¹1 IQVIA, New York, NY, USA.

Therapeutic Innovation & Regulatory Science

|July 25, 2018

Summary

This study introduces a new Evidence-Based Valuation (EBV) framework to determine drug pricing. EBV helps estimate value-based pricing ranges by identifying key attributes and evidence needed for pharmaceuticals.

Keywords:

evidence-based value framework pricing in oncology value demonstration in health care

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Published on: January 21, 2019

Area of Science:

Health Economics
Pharmaceutical Pricing
Evidence-Based Medicine

Background:

Demonstrating healthcare value is a persistent challenge.
Traditional pricing models are evolving towards value-based pricing (VBP).
A new framework for evidence-based valuation (EBV) is proposed.

Purpose of the Study:

To estimate the value-based pricing range for new medicines.
To identify key product attributes influencing stakeholder value perception.
To determine the evidence required to support value claims.

Main Methods:

EBV utilizes a structured framework to estimate drug prices based on stakeholder-perceived value.
Key value attributes driving drug adoption are identified.
Stakeholder value considerations, evidence requirements, and perceptions are quantified.

Main Results:

The EBV framework was applied to drugs for renal cell carcinoma, prostate cancer, and melanoma.
Analysis of Health Technology Assessments (HTAs) and PubMed publications (2005-2013) identified key value attributes.
Attributes analyzed included overall survival (OS), progression-free survival (PFS), population size, trial comparator, and adverse events.

Conclusions:

The described EBV method provides a means to appraise pharmaceuticals.
This approach is suitable for the current healthcare landscape emphasizing evidence-based medicine and value-based care.