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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
[Clinical Evaluation of A New Pathological Classification for Non-small Cell Lung Cancer Based on Histogenesis of
Nana Wang1, Nan Jiang2, Xiaoqing Yang1
1Department of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, China.
Background:
Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree.
Methods:
Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.
Results:
Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.
Conclusions:
The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
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