Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

295
Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
295
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

335
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
335
Molecular Models02:00

Molecular Models

43.8K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.8K
The Bohr Model02:18

The Bohr Model

81.0K
Following the work of Ernest Rutherford and his colleagues in the early twentieth century, the picture of atoms consisting of tiny dense nuclei surrounded by lighter and even tinier electrons continually moving about the nucleus was well established. This picture was called the planetary model since it pictured the atom as a miniature “solar system” with the electrons orbiting the nucleus like planets orbiting the sun. The simplest atom is hydrogen, consisting of a single proton as the...
81.0K
Stereotype Content Model02:16

Stereotype Content Model

15.5K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.5K
The Quantum-Mechanical Model of an Atom02:45

The Quantum-Mechanical Model of an Atom

59.0K
Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of a particle moving in quantized circular orbits, Erwin Schrödinger extended de Broglie’s work by deriving what is now known as the Schrödinger equation. When Schrödinger applied his equation to hydrogen-like atoms, he was able to reproduce Bohr’s expression for the energy and, thus, the Rydberg formula governing hydrogen spectra.
59.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploratory comparison of PASC and SARS-CoV-2 infection through metabolomics and lipidomics in early pandemic and Omicron-era.

Biochemistry and biophysics reports·2026
Same author

Characterizing the effects of MSC lipid remodeling via sphingomyelinase licensing through morphological, metabolic, and secretome profiling.

Cytotherapy·2026
Same author

Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies.

Materials today. Advances·2026
Same author

Analytical comparison of over-the-counter multiplex tests for influenza A, influenza B, and SARS-CoV-2.

Microbiology spectrum·2026
Same author

Model-based clustering of multiple images incorporating covariates.

Statistical methods in medical research·2026
Same author

Peak Nasal SARS-CoV-2 and Influenza Viral Loads Relative to Symptom Onset, 2022-2025: Impact of Vaccination and Implications for Multiplexed Testing.

The Journal of infectious diseases·2026
Same journal

Quantification of cell viability by automated analysis of live cell imaging.

Methods in cell biology·2026
Same journal

Flow cytometry evaluation of cytotoxicity exerted by effector immune cells against tumor cells.

Methods in cell biology·2026
Same journal

Time-lapse confocal laser scanning microscopy analysis of FOOD formation.

Methods in cell biology·2026
Same journal

Screening and identification of protein-protein interaction using proximity labeling.

Methods in cell biology·2026
Same journal

Quantitative high-content profiling of mitochondrial morphology with automated statistical analysis and integrated data visualization.

Methods in cell biology·2026
Same journal

Super-resolution imaging of cell death in Drosophila tissues via expansion and pan-expansion microscopy.

Methods in cell biology·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

839

3D in vitro microvascular model-based lymphoma model.

Robert G Mannino1, Pallab Pradhan1, Krishnendu Roy1

  • 1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; Department of Pediatrics, Division of Pediatric Hematology/Oncology Aflac Cancer Center and Blood Disorders Center of Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, United States.

Methods in Cell Biology
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel DLBCL-on-chip model to study tumor microenvironment interactions. This accessible microfluidic platform aids in understanding diffuse large B-cell lymphoma (DLBCL) pathophysiology and developing new therapies.

Keywords:
LymphomaMicrofluidicsPDMSTumor vasculatureTumor-on-chip

More Related Videos

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

7.3K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Related Experiment Videos

Last Updated: Feb 7, 2026

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

839
Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

7.3K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer affecting ~20,000 US individuals annually.
  • Understanding the DLBCL tumor microenvironment is critical for developing effective therapies.
  • Existing in vivo models are complex; in vitro platforms are needed to mimic cellular interactions.

Purpose of the Study:

  • To present a method for fabricating an in vitro DLBCL-on-chip model.
  • To create a platform that recapitulates DLBCL tumor microenvironment attributes and cellular interactions.
  • To provide an accessible tool for researching the DLBCL tumor microenvironment.

Main Methods:

  • Fabrication of a microfluidic device containing a vascularized, perfusable channel.
  • Incorporation of a DLBCL tumor cell-laden hydrogel within the microfluidic system.
  • Development of a model that mimics key aspects of the in vivo tumor microenvironment.

Main Results:

  • The DLBCL-on-chip model successfully recapitulates hallmark attributes of the tumor microenvironment.
  • It enables the study of complex cellular interactions within the DLBCL microenvironment.
  • The fabrication method avoids traditional photolithography, using common lab items.

Conclusions:

  • This microfluidic DLBCL-on-chip model offers a simplified yet effective in vitro system.
  • It provides a vital tool for researchers to explore the DLBCL tumor microenvironment.
  • The accessible nature of the platform can advance therapeutic strategy development for DLBCL.