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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Electrical Current01:10

Electrical Current

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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Current Density01:21

Current Density

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The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
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[Cultured platelets].

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Functional properties of human platelets derived in vitro from CD34<sup>+</sup> cells.

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Title of the study: Corrected Count Increment as a Predictor of Early Graft Dysfunction and Mortality Following Living Donor Liver Transplantation.

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Related Experiment Video

Updated: Feb 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
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Routine Screening Method for Microparticles in Platelet Transfusions

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Platelet transfusion: Current challenges.

C Humbrecht1, D Kientz1, C Gachet1

  • 1Établissement français du sang grand est, 85-87, boulevard Lobau, 54064 Nancy cedex, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

Platelet transfusions are vital for patients with low platelet counts or bleeding risks. Current practices vary, and ongoing debates address optimal dosing, quality, and safety of platelet concentrates.

Keywords:
BleedingBlood productPlaquettesPlateletsProduit sanguinSafetySaignementSécuritéTransfusion

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Area of Science:

  • Hematology
  • Transfusion Medicine

Background:

  • Platelet concentrates (PCs) have been transfused since the late 1960s for thrombocytopenia, platelet dysfunction, injuries, and surgery.
  • Current transfusion practices for PCs exhibit significant international and inter-institutional variability.
  • Despite advances, critical questions persist regarding optimal transfusion strategies and PC quality.

Purpose of the Study:

  • To review and discuss the most debated aspects of platelet transfusion.
  • To highlight current challenges and emerging innovations in platelet products.

Main Methods:

  • Literature review of current practices and ongoing debates in platelet transfusion.
  • Synthesis of information on dosing, prophylactic vs. therapeutic strategies, PC quality, storage, efficacy monitoring, and safety.

Main Results:

  • Significant variability exists in current platelet transfusion protocols globally.
  • Key areas of debate include optimal dosing, prophylactic strategies, PC quality control, storage methods, and transfusion efficacy monitoring.
  • Emerging challenges involve the development and integration of novel platelet products, such as cold-stored and in vitro-produced platelets.

Conclusions:

  • Standardization of platelet transfusion practices is needed.
  • Further research and consensus are required to address current debates and ensure the safety and efficacy of platelet transfusions.
  • Innovation in platelet products presents new opportunities and challenges for transfusion medicine.