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Related Experiment Videos

Does Intravenous Lactated Ringer's Solution Raise Serum Lactate?

Tony Zitek1, Zachary D Skaggs2, Aryan Rahbar3

  • 1School of Medicine, University of Nevada, Las Vegas, Las Vegas, Nevada; University Medical Center of Southern Nevada, Las Vegas, Nevada; Kendall Regional Medical Center, Miami, Florida.

The Journal of Emergency Medicine
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

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Lactated Ringer's (LR) solution can increase serum lactate levels in healthy individuals. However, a 30 mL/kg bolus of LR did not significantly increase serum lactate compared to normal saline (NS).

Area of Science:

  • Critical Care Medicine
  • Emergency Medicine
  • Clinical Chemistry

Background:

  • Serum lactate is a marker for sepsis and shock, but its interpretation can be confounded.
  • Lactated Ringer's (LR) solution, used in resuscitation, contains sodium lactate.

Purpose of the Study:

  • To determine if a 30 mL/kg intravenous bolus of LR increases serum lactate levels.
  • To compare the effect of LR versus normal saline (NS) on serum lactate.

Main Methods:

  • A double-blind, randomized controlled trial involving 30 healthy volunteers.
  • Participants received either 30 mL/kg of LR or NS intravenously.
  • Serum lactate, pH, bicarbonate, sodium, and chloride were measured before and after fluid administration.
Keywords:
isotonic fluidslactatelactated Ringer'sresuscitationsepsis

Related Experiment Videos

Main Results:

  • A modest increase in mean serum lactate (0.93 mmol/L) was observed after LR administration.
  • A smaller increase in mean serum lactate (0.37 mmol/L) occurred in the normal saline group.
  • No statistically significant difference in lactate change was found between the LR and NS groups (p=0.2).

Conclusions:

  • In healthy individuals, a 30 mL/kg LR bolus causes a slight increase in serum lactate.
  • There was no significant difference in serum lactate changes when comparing LR to NS boluses.
  • Normal saline boluses resulted in greater declines in pH and bicarbonate compared to LR.