High-speed recording of thermal load during laser trans-epithelial corneal refractive surgery using a 750Hz ablation...

To evaluate the temperature rise of human cornea during trans-epithelial photorefractive keratectomy (trans-PRK) with a 750Hz excimer laser employing Intelligent Thermal Effect Control (ITEC) software.

In this observational case series, trans-PRK ablation was performed on 5 eyes of 3 patients using an aspheric profile of a 750Hz excimer laser system. A high-resolution infrared camera with a frame-rate of 350 images per second was used to determine the corneal surface temperature. Images were taken sequentially, starting a few seconds prior to and ending a few seconds after the ablation. The maximum temperature of any pixel of a given image were recorded and graphed against time.

The baseline ocular surface temperature, immediately prior to the beginning of excimer laser, ranged from 32 to 34.9°C. The maximum ocular surface temperature until the epithelium was ablated ranged from 35.2 to 39.7°C. The maximum ocular surface temperature during stromal ablation with high and low fluence laser ranged from 32.9 to 36.5 and from 34.4 to 37.7°C respectively.

The ITEC software is effective in controlling the maximum temperature rise during laser ablation in the extremely challenging situation of trans-PRK involving high ablation volumes of almost 6000nl, potentially improving the outcomes. The ITEC system limited the maximum temperature to 39.7°C in the epithelium, and 37.7°C in the stroma. The epithelial temperature was always higher than stromal temperature (regardless of high or low fluence irradiation). Safety limit of 40°C found in the literature was never reached.