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Spatial Separation of Molecular Conformers and Clusters
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Assessing spatial pattern separation in rodents using the object pattern separation task.

Nick P van Goethem1, Britt T J van Hagen1, Jos Prickaerts2

  • 1Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.

Nature Protocols
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Summary

This study introduces a simple object pattern separation (OPS) task for rodents, crucial for understanding episodic memory and cognitive disorders. The OPS task offers a cost-effective and straightforward method for assessing spatial pattern separation in research settings.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Animal Behavior

Background:

  • Pattern separation, a hippocampal function, is vital for episodic memory.
  • Impaired pattern separation is linked to cognitive decline in dementia, schizophrenia, and PTSD.
  • Existing tasks for assessing pattern separation can be complex and costly.

Purpose of the Study:

  • To present a simple, robust, and validated object pattern separation (OPS) task for mice and rats.
  • To provide a cost-effective and easily interpretable method for assessing spatial pattern separation.
  • To enable bidirectional detection of spatial pattern separation performance.

Main Methods:

  • The protocol details a two-trial memory task using specific object locations and movement calibration.
  • Animals undergo vivarium acclimatization and training over approximately 35-41 days.
  • The task is designed for repeated testing and integration into existing rodent behavioral batteries.

Main Results:

  • The OPS task allows for performance calibration based on object displacement, indicating spatial pattern separation.
  • It offers a bidirectional assessment of spatial pattern separation capabilities.
  • The task is more economical and simpler to implement and interpret compared to other methods.

Conclusions:

  • The OPS task provides a valuable and accessible tool for studying spatial pattern separation in rodents.
  • This method can aid in understanding the neural mechanisms underlying memory and cognitive disorders.
  • The task's simplicity and cost-effectiveness make it suitable for various research laboratories.