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New PDL1 inhibitors for non-small cell lung cancer: focus on pembrolizumab

Olivier Bylicki1, Nicolas Paleiron2, Gaëlle Rousseau-Bussac3

  • 1Pneumology Department, Hôpital d'Instruction des Armées Percy, Paris, bylicki.olivier@yahoo.fr.

Oncotargets and Therapy
|July 25, 2018
PubMed

Insights

Immune-checkpoint inhibitors like pembrolizumab offer new hope for advanced non-small cell lung cancer (NSCLC). These therapies, targeting PD1/PDL1, show promising activity and durable responses in patients with NSCLC.

Area of Science:

  • Oncology
  • Immunotherapy
  • Personalized Medicine

Background:

  • Platinum-based chemotherapy for non-small cell lung cancer (NSCLC) has limitations due to toxicity and plateaued efficacy.
  • Immune-checkpoint inhibitors targeting PD1 and PDL1 have emerged as a significant advancement in NSCLC treatment.

Purpose of the Study:

  • To review the clinical results of studies evaluating pembrolizumab in advanced NSCLC.
  • To assess the potential of PDL1 as a predictive biomarker for treatment response.

Main Methods:

  • Analysis of published and ongoing clinical studies on pembrolizumab for advanced NSCLC.
  • Evaluation of PDL1 expression as a predictive factor for overall response.

Main Results:

  • Pembrolizumab demonstrates promising clinical activity and durable responses in advanced NSCLC.
  • Regulatory approvals exist for pembrolizumab in specific NSCLC patient populations based on PDL1 expression.
  • Combination therapy with pembrolizumab and chemotherapy is being investigated.

Conclusions:

  • Immune-checkpoint inhibitors, particularly pembrolizumab, represent a major advancement in NSCLC treatment.
  • PDL1 expression is a key factor in patient selection for pembrolizumab therapy.
  • Further research is ongoing to optimize the use of pembrolizumab in NSCLC.
Keywords:
NSCLCPDL1immune-checkpoint inhibitorpembrolizumab

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