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Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling

Jiejie Zhao1,2, Yang Jiao1,2, Yuping Song3

  • 1Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Physiology
|July 25, 2018
PubMed

Insights

Stanniocalcin 2 (STC2) deficiency worsens fatty liver in obese mice. STC2 administration reduces liver fat and triglycerides by inhibiting fat-producing genes via the STAT3 pathway.

Area of Science:

  • Endocrinology
  • Metabolic research
  • Molecular biology

Background:

  • Stanniocalcin 2 (STC2) is a secreted glycoprotein hormone involved in various biological processes.
  • The role of STC2 in hepatic triglyceride metabolism and its potential link to obesity-related liver diseases are currently unknown.

Purpose of the Study:

  • To investigate the role of STC2 in regulating hepatic triglyceride metabolism.
  • To explore STC2 as a potential therapeutic target for fatty liver disease.

Main Methods:

  • Studied STC2 expression in livers of obese mouse models (leptin-deficient and high-fat diet-induced).
  • Administered STC2 recombinant protein and used adenovirus-mediated STC2 overexpression in obese mice.
  • Investigated the effect of STC2 on lipogenic gene expression and the STAT3 signaling pathway both *in vivo* and *in vitro*.

Main Results:

  • STC2 expression was significantly reduced in the livers of obese mice.
  • STC2 administration or overexpression attenuated hepatosteatosis and hypertriglyceridemia in obese mice.
  • STC2 activated the STAT3 signaling pathway, leading to inhibition of lipogenic gene expression; STAT3 inhibition abolished STC2's anti-steatotic effects.

Conclusions:

  • STC2 plays a crucial role in regulating hepatic triglyceride metabolism.
  • STC2 demonstrates potential as a therapeutic target for fatty liver and associated metabolic disorders.
Keywords:
STAT3lipogenesisnon-alcoholic fatty liver diseasestanniocalcin 2triglyceride metabolism

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