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Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by

Dilidaer Muhanhali1, Tianyu Zhai1, Jingjing Jiang1

  • 1Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.

Frontiers in Endocrinology
|July 25, 2018
PubMed

Insights

Long non-coding RNA TNRC6C-AS1 promotes papillary thyroid cancer (PTC) progression by suppressing TNRC6C. Targeting this axis may offer new PTC treatment strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Long non-coding antisense RNAs play crucial roles in regulating their cognate sense genes in cancer.
  • Understanding these regulatory mechanisms is vital for developing targeted cancer therapies.

Purpose of the Study:

  • To investigate the regulatory role of TNRC6C-AS1 on its sense partner TNRC6C.
  • To determine the effects of this axis on papillary thyroid cancer (PTC) aggressiveness and iodine uptake.

Main Methods:

  • Microarray and computational analysis identified TNRC6C-AS1 in PTC.
  • In vitro gain/loss-of-function experiments assessed TNRC6C-AS1 and TNRC6C effects on TPC1 cells.
  • Expression levels of TNRC6C-AS1 and TNRC6C were analyzed in PTC tissues and adjacent normal tissues.

Main Results:

  • Downregulation of TNRC6C-AS1 or overexpression of TNRC6C inhibited PTC cell proliferation, migration, and invasion, while promoting apoptosis and iodine uptake.
  • TNRC6C-AS1 knockdown increased TNRC6C expression, and this effect was dependent on TNRC6C.
  • TNRC6C-AS1 was upregulated, and TNRC6C was downregulated in PTC tissues, showing an inverse correlation.

Conclusions:

  • TNRC6C-AS1 promotes PTC progression and reduces iodine accumulation by suppressing TNRC6C.
  • The TNRC6C-AS1-TNRC6C axis represents a potential therapeutic target for papillary thyroid cancer.
Keywords:
TNRC6CTNRC6C-AS1iodine accumulationlong non-coding antisense RNApapillary thyroid cancer

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