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Cutaneous side effects of molecularly targeted therapies for the treatment of solid tumors

Daniel I G Cubero1, Beatrice Martinez Zugaib Abdalla2, Jean Schoueri3

  • 1Department of Oncology and Hematology, ABC Foundation School of Medicine, Av Principe de Gales, 821, Santo André/SP - Brazil, ZIP 09060-650.

Drugs in Context
|July 25, 2018
PubMed
Abstract

Insights

Molecularly targeted cancer therapies can cause skin side effects. Early identification and treatment of these cutaneous reactions improve patient quality of life and cancer treatment adherence.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Molecularly targeted drugs are crucial in cancer therapy, improving patient survival and quality of life.
  • These targeted therapies, while effective against cancer cells, can also affect normal cells, leading to side effects.

Purpose of the Study:

  • To review the cutaneous side effects associated with major molecularly targeted cancer therapies for solid tumors.
  • To provide a comprehensive overview of adverse skin reactions caused by these advanced cancer treatments.

Main Methods:

  • Literature review of molecularly targeted cancer therapies and their associated side effects.
  • Focus on adverse cutaneous events in patients with solid tumors.

Main Results:

  • The skin is a frequently affected organ by molecularly targeted cancer drugs.
  • This review details various adverse cutaneous effects stemming from these targeted therapies.

Conclusions:

  • Recognizing these skin reactions is vital for both dermatologists and oncologists.
  • Proper diagnosis and management of cutaneous side effects enhance patient adherence to cancer treatment and improve overall quality of life.
Keywords:
adverse reactionschemotherapydermatologydrug-related side effectsimmunotherapyoncologyskintargeted therapy

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