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Updated: Feb 7, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate
Vicki E Maltby1,2, Rodney A Lea2,3, Karen A Ribbons2,4
1School of Medicine and Public Health, University of Newcastle, Australia.
Background:
Dimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood.
Objective:
To investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients.
Methods:
We performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment.
Results:
Treatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site.
Conclusion:
This study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
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