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Updated: Feb 7, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
Published on: May 21, 2018
Lead Identification Through the Synergistic Action of Biomolecular NMR and In Silico Methodologies
Konstantinos D Marousis1, Aikaterini C Tsika1, Maria Birkou1
1Department of Pharmacy, University of Patras, Patras, Greece.
Abstract:
The combination of virtual screening with biomolecular NMR can be a powerful approach in the first steps toward drug discovery. Here, we describe how computational methodologies to screen large databases readily available for testing small molecules, in synergy with NMR techniques focused on protein-ligand interactions, can be used in the early lead compound identification process against a protein drug target.
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