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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.7K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Related Experiment Video

Updated: Feb 7, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

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Stem Cell Therapy for Multiple Sclerosis.

Bilgesu Genc1, Hemdem Rodi Bozan2, Sermin Genc3,4

  • 1Department of Molecular Biology and Genetics, Izmir Institute of Technology, Izmir, Turkey.

Advances in Experimental Medicine and Biology
|July 25, 2018
PubMed
Summary

Stem cell therapy offers a promising alternative for multiple sclerosis (MS) by addressing neuronal loss and remyelination failure. Research shows potential for various stem cell types to repair CNS damage and improve neurological function in MS patients.

Keywords:
Experimental autoimmune encephalomyelitisHematopoietic stem cellInduced pluripotent stem cellMesenchymal stem cellMultiple sclerosisNeural stem cellReprogrammingStem cell therapy

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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
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Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) is a chronic CNS disease causing demyelination, neuronal loss, and disability.
  • Current therapies are insufficient, failing to halt neurodegeneration.
  • Complex pathogenesis involves autoimmune attacks and remyelination failure.

Purpose of the Study:

  • To explore cell replacement therapy as an alternative treatment for MS.
  • To review stem cell sources and applications for MS treatment.
  • To discuss challenges and future prospects of stem cell therapy in MS.

Main Methods:

  • Overview of preclinical studies using the experimental autoimmune encephalomyelitis model.
  • Analysis of stem cell types including mesenchymal stem cells (MSCs), neural stem cells, and induced-pluripotent stem cells.
  • Review of ongoing autologous hematopoietic stem cell therapy studies.

Main Results:

  • Grafted stem cells demonstrate potential in repairing CNS lesions and recovering neurological deficits.
  • Autologous hematopoietic stem cell therapy shows feasibility for immunomodulatory treatment.
  • Preclinical data supports the efficacy of various stem cell types in MS models.

Conclusions:

  • Cell replacement therapy is a viable option for MS, aiming to overcome neuronal loss and enhance myelin repair.
  • Challenges include administration, immune response, cell integration, and tumor risk.
  • Stem cell therapy holds significant future prospects for treating multiple sclerosis.