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Updated: Feb 7, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
Foot measures in patients with pes cavus with and without charcot-marie-tooth disease: A pilot study
Amro M Stino1, Said Atway2, Michael Anthony2
1Ohio State University Wexner Medical Center Department of Neurology, Division of Neuromuscular Medicine, Columbus, Ohio, USA.
Introduction:
Pes cavus often signals the presence of Charcot-Marie-Tooth (CMT) in adult patients, although its prevalence in the general population makes it a finding of unclear significance.
Methods:
We undertook a pilot double cohort study to investigate the feasibility of comparing preselected bedside and radiographic foot measures in pes cavus patients with and without CMT.
Results:
A total of 16 CMT and 11 non-CMT patients were recruited. Although no findings consistently met statistical significance, recruitment was highly limiting.
Conclusions:
Formalized foot measurement comparisons of CMT and non-CMT pes cavus are feasible. Larger studies will be necessary to determine if there are differences in foot structure based on the presence of a hereditary neuropathy. Muscle Nerve 59:122-125, 2019.
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