Motility of the left colon in children and adolescents with functional constpation; a retrospective comparison

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I J N Koppen1,2, L Wiklendt3, D Yacob1

  • 1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.

Neurogastroenterology and Motility
|July 25, 2018
PubMed

Insights

Children with functional constipation lack normal colonic motor patterns after meals, regardless of the manometry catheter used. This suggests a consistent underlying pathology in functional constipation.

Area of Science:

  • Gastroenterology
  • Pediatric Gastroenterology
  • Colorectal Physiology

Background:

  • Previous studies using water-perfused (WP) manometry showed children with functional constipation (FC) lack postprandial distal colonic motor patterns.
  • This study aimed to validate these findings using solid-state (SS) manometry.

Purpose of the Study:

  • To determine if SS manometry could detect the same abnormal colonic motor patterns in children with FC as previously observed with WP manometry.
  • To assess if the type of manometry catheter influences the detection of colonic motor abnormalities in FC.

Main Methods:

  • Retrospective analysis of 19 children with FC using SS manometry (36 sensors, 3 cm apart).
  • Comparison with previously published WP manometry data from 18 children with FC (36 sensors, 1.5 cm apart).

Main Results:

  • SS and WP manometry recordings of cyclic motor patterns were comparable.
  • Neither catheter type detected a postprandial increase in distal colonic motor patterns in children with FC.
  • High-amplitude propulsive colonic contractions (HAPCs) were observed similarly in both SS and WP data.

Conclusions:

  • SS manometry yields results consistent with WP manometry for assessing colonic motor patterns in children with FC.
  • The observed abnormal colonic response to meals in FC is independent of the manometry catheter type.
  • Findings indicate a consistent colonic motor abnormality in functional constipation not related to the measurement method.
Abstract

Keywords:
childrencolonic manometryconstipationmotility

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