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Related Experiment Video

Updated: Feb 7, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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Functional and anatomical connectivity-based parcellation of human cingulate cortex.

Fei Jin1, Pengpeng Zheng1, Huaigui Liu1

  • 1Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China.

Brain and Behavior
|July 25, 2018
PubMed
Summary
This summary is machine-generated.

Researchers parcellated the human cingulate cortex (CC) using functional and anatomical MRI data. This study established an internally consistent CC subregion map, aiding future in vivo brain studies.

Keywords:
anatomical connectivitycingulate cortexfunctional connectivitymagnetic resonance imagingparcellation

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Brain Anatomy

Background:

  • The human cingulate cortex (CC) is involved in numerous functions, suggesting specialized subregions.
  • Understanding these subregions is crucial for comprehending CC's complex roles.

Purpose of the Study:

  • To parcellate the human CC using resting-state functional connectivity (rsFC) and anatomical connectivity (AC) patterns.
  • To analyze the connectivity profiles of identified CC subregions.
  • To assess the consistency between functional and anatomical parcellation methods.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI).
  • Applied both rsFC and AC patterns for CC parcellation.
  • Compared and analyzed the resulting functional and anatomical subregions.

Main Results:

  • The CC was divided into six functional subregions and ten anatomical subregions (S1-S10).
  • Each subregion exhibited distinct connectivity patterns.
  • High internal consistency was observed within both functional and anatomical parcellations.

Conclusions:

  • A novel, internally consistent parcellation scheme for the human CC was established using multimodal MRI.
  • This scheme provides an in vivo guide for subregion-specific research on the CC.
  • The findings enhance the understanding of the human CC at a subregional level.