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Volume calculation often begins with simple geometric solids. For example, the volume of a rectangular box is obtained by multiplying the area of its base by its height. This straightforward approach relies on the fact that the cross-sectional area of the box remains constant throughout its length. Many real-world objects, however, do not have uniform cross-sections, and their volumes cannot be determined using elementary geometric formulas.To address this limitation, the Slicing Method...

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Related Experiment Video

Updated: Feb 7, 2026

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

Solid-State Microfluidics with Integrated Thin-Film Acoustic Sensors.

Menglun Zhang¹, Jingze Huang², Yao Lu¹

¹State Key Laboratory of Precision Measuring Technology and Instruments , Tianjin University , Tianjin 300072 , China.

|July 25, 2018

Summary

This study introduces a portable, solid-state microfluidic chip with integrated acoustic sensors for point-of-care diagnostics. The chip enables label-free immunoassays, offering a compact and efficient solution for clinical settings.

Keywords:

acoustic wave sensors biosensors monolithic integration point-of-care thin film microfluidics

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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Area of Science:

Microfluidics
Sensor Technology
Biotechnology

Background:

Integrating sensors into microfluidic chips for point-of-care use is challenging due to bulky conventional modules and incompatible fabrication processes.
Existing acoustic sensors face performance degradation in liquid-phase sensing, limiting their application in microfluidic devices.

Purpose of the Study:

To introduce a novel solid-state microfluidic chip with integrated on-chip acoustic sensors.
To demonstrate a portable and compact solution for microfluidic-based diagnostics.
To address the performance degradation of acoustic sensors in liquid-phase sensing.

Main Methods:

Fabrication of a solid-state microfluidic chip using standard thin-film technologies on a silicon substrate.
Integration of on-chip acoustic sensors for electrical read-out.
Development of a system for processing discrete microdroplets.
Conducting label-free immunoassays in serum, including prostate-specific antigen sensing.

Main Results:

The integrated chip features a compact, portable design with electrical input for fluid control and electrical output for sensor read-out.
The microdroplet processing approach mitigates performance degradation of acoustic sensors in liquid-phase sensing.
Successful label-free immunoassays were performed, with results comparable to commercial ELISA for prostate-specific antigen detection.

Conclusions:

The developed solid-state microfluidic chip offers a viable, portable platform for point-of-care diagnostic applications.
The chip's design and functionality are suitable for personalized diagnostics and clinical settings prioritizing instrument portability.