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High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
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Dynamic volumetric changes of hippocampal subfields in clinically isolated syndrome patients: A 2-year MRI study

Laura Cacciaguerra1, Elisabetta Pagani2, Sharlota Mesaros3

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 25, 2018
PubMed
Abstract

Insights

Regional hippocampal changes occur in clinically isolated syndrome (CIS) patients, particularly in those who convert to multiple sclerosis (MS). These changes are linked to white matter lesions and impact prognosis.

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Research

Background:

  • Hippocampal involvement varies across multiple sclerosis (MS) phenotypes.
  • Understanding these variations is crucial for early diagnosis and prognosis.

Purpose of the Study:

  • To investigate regional hippocampal variations in clinically isolated syndrome (CIS) patients.
  • To correlate these variations with white matter (WM) lesions and cognitive function.
  • To assess the prognostic implications of hippocampal changes in CIS.

Main Methods:

  • Acquired brain MRI scans (dual-echo, 3D T1-weighted) from 36 CIS patients and 14 healthy controls.
  • Utilized 3D parametric surface mesh models to assess radial distance distribution in the hippocampus.
  • Performed cognitive screening at multiple time points post-onset.

Main Results:

  • CIS patients exhibited reduced radial distance in Cornu Ammonis 1 and subiculum, correlating with WM lesion volume.
  • Increased radial distance was observed in the dentate gyrus, also linked to lesion load.
  • Hippocampal volume changes were more pronounced in patients who later converted to MS.

Conclusions:

  • Regional hippocampal alterations are present in CIS and are influenced by WM lesions.
  • These changes are more significant in patients progressing to MS.
  • Hippocampal variations in CIS do not appear to correlate with cognitive performance in this study.
Keywords:
MRIShape analysisdentate gyrushippocampuslongitudinal analysismultiple sclerosis

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