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Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A
Yongyan Gao1, Jian Zheng1, Ping Liang1
1From the Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China (Y.G., P.L.); Department of Ultrasound, The General Hospital of Chinese People's Armed Police Forces, Beijing, China (Y.G.); Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China (J.Z., R.Z.); Department of Ultrasound, Third People's Hospital of Longgang District of Shenzhen, Shenzhen, China (J.Z.); Functional Examination Department of Children's Hospital, Lanzhou University Second Hospital, Lanzhou, China (M.T., J.W.); Ultrasound Department, The First Affiliated Hospital of Harbin Medical University, Harbin, China (C.W., X.H.); Ultrasound Department, Guangzhou the Eighth People's Hospital, Guangzhou, China (C.L., S.Z.); Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China (L.H.); Department of Ultrasonography, the First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China (T.J., C.C.); Function Diagnosis Center, Beijing Youan Hospital, Affiliated to Capital Medical University, Beijing, China (F.M., X.M.); Ultrasound Department, The Second People's Hospital of Yunnan Province, Kunming, China (Y. Lu, Y. Li); Ultrasound Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China (H.A., X.Q.); Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (X.Y.X., W.W.); and Department of Ultrasound, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM, Nanjing, China (L.P.Y., Y.Y.W.).
Abstract:
Purpose To investigate the diagnostic performance of two-dimensional (2D) shear-wave elastography (SWE) in chronic hepatitis B. Materials and Methods This prospective multicenter study from January 2015 to January 2016 was conducted at 12 hospitals and included 654 participants with chronic hepatitis B who had undergone liver biopsy and 2D SWE examination. Participants were divided into chronic infection and chronic hepatitis groups. The diagnostic performance of 2D SWE was compared with the aspartate amino transferase-to-platelet ratio index (APRI), the Fibrosis-4 index (FIB-4), and transient elastography (TE) by using a DeLong test and was also compared between two subgroups. Dual cutoff values for cirrhosis were determined with multilevel likelihood ratio analysis. Results Overall, 402 participants with chronic hepatitis B were enrolled (154 with chronic infection and 248 with chronic hepatitis). The areas under the receiver operating characteristic curve of 2D SWE (0.87; 95% confidence interval [CI]: 0.83, 0.90) were higher than those of TE (0.80; 95% CI: 0.68, 0.88), APRI (0.70; 95% CI: 0.65, 0.74), and FIB-4 (0.73; 95% CI: 0.69, 0.78) in cirrhosis. The high area under the receiver operating characteristic curve (0.92; 95% CI: 0.87, 0.96) was achieved in the chronic infection group and was significantly higher than that of the chronic hepatitis group (0.84; 95% CI: 0.78, 0.88; P = .017). Dual cutoff values with the likelihood ratios below 0.1 and above 10 (8.4 kPa and 11.0 kPa to rule out and rule in a diagnosis of cirrhosis, respectively) were effectively determined in chronic infection; a total of 81.2% (125 of 154) participants with cirrhosis were definitively diagnosed. Conclusion The performance of two-dimensional (2D) shear-wave elastography (SWE) was higher than that of other noninvasive methods. 2D SWE was most effective in ruling in and ruling out cirrhosis in participants with chronic infection, which may prompt antiviral treatment. © RSNA, 2018 Online supplemental material is available for this article.
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