Related Experiment Video

Updated: Feb 7, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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[Percutaneous left atrial appendage closure for stroke prevention in atrial fibrillation: is left atrial appendage

Lucas V A Boersma1,2, Benno J W M Rensing1, Lisette I Wintgens1

  • 1St. Antonius Ziekenhuis, afd. Cardiologie, Nieuwegein.

Nederlands Tijdschrift Voor Geneeskunde
|July 25, 2018
PubMed

Insights

Left atrial appendage closure is a safe and effective stroke prevention method for atrial fibrillation patients, offering an alternative to oral anticoagulation with reduced bleeding risks.

Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • The left atrial appendage (LAA) is a primary source of cardioembolic stroke in atrial fibrillation (AF) patients.
  • Oral anticoagulation (OAC) is effective for stroke prevention in AF but carries bleeding risks and compliance issues.

Purpose of the Study:

  • To evaluate percutaneous left atrial appendage closure as an alternative to OAC for stroke prevention in AF.
  • To assess the safety and efficacy of LAA closure devices, such as the WATCHMAN device.

Main Methods:

  • Review of randomized trials and prospective registry studies comparing LAA closure with OAC.
  • Analysis of stroke prevention rates and bleeding complications associated with LAA closure.

Main Results:

  • LAA closure is non-inferior to OAC for stroke prevention.
  • LAA closure demonstrates a reduction in bleeding events compared to OAC.
  • Registry studies confirm LAA closure as a viable alternative for patients with OAC contraindications.

Conclusions:

  • Percutaneous LAA closure is a safe and effective alternative to OAC for stroke prevention in AF patients, particularly those at high risk of bleeding.
  • Ongoing research aims to further optimize LAA closure techniques and compare them with newer anticoagulant therapies.

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