Related Experiment Video

Updated: Feb 7, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
14:54

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

9.1K

Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies

Jeffrey J Yu1, Daniel H Lee1, Shea P Gallagher1

  • 1a Department of Ophthalmology , University of California , Irvine , CA , USA.

Current Eye Research
|July 25, 2018
PubMed

Insights

Certain antibiotics can cause toxic optic neuropathy by impairing mitochondrial function. This review examines the prevalence, symptoms, and treatment of this condition, focusing on its impact on the optic nerve.

Area of Science:

  • Neuroscience
  • Toxicology
  • Ophthalmology

Background:

  • Mitochondrial dysfunction is increasingly implicated in toxic optic neuropathies.
  • Antibiotics targeting bacterial machinery may affect similar mitochondrial components.
  • Several antibiotics are known to induce optic nerve damage.

Purpose of the Study:

  • To review the literature on antibiotic-induced toxic optic neuropathies.
  • To discuss their prevalence, clinical features, and management.
  • To explore the specific effects of these antibiotics on optic nerve mitochondrial function.

Main Methods:

  • Literature review of existing studies.
  • Analysis of clinical manifestations and prevalence data.
  • Discussion of the mechanistic link between antibiotics and mitochondrial dysfunction in the optic nerve.

Main Results:

  • Antibiotic-induced toxic optic neuropathy is a recognized clinical entity.
  • Clinical presentation varies, but visual impairment is common.
  • Mitochondrial toxicity is a key mechanism underlying optic nerve damage.

Conclusions:

  • Understanding the mitochondrial effects of antibiotics is crucial for managing toxic optic neuropathies.
  • Early recognition and potential intervention can mitigate visual loss.
  • Further research into specific antibiotic-mitochondria interactions is warranted.
Keywords:
Toxic optic neuropathyantibiotic-induced optic neuropathyethambutol-induced optic neuropathylinezolid-induced optic neuropathymitochondrial optic neuropathy

More Related Videos

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy rNAION

Published on: November 20, 2016

9.4K
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

7.8K

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
60.0K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.4K
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.2K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.5K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.7K