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Behavioral Variant Frontotemporal Dementia Performance on a Range of Saccadic Tasks
Amanda Douglass1,2, Mark Walterfang3,4,5, Dennis Velakoulis3,4
1Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia.
Journal of Alzheimer'S Disease : JAD
|July 25, 2018
Summary
Behavioral variant frontotemporal dementia (bvFTD) patients show altered eye movements across multiple saccadic tasks. These changes, including increased latency and errors, reflect frontal lobe dysfunction in bvFTD.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Saccadic paradigms reveal oculomotor pathway changes in degenerative conditions.
- These oculomotor changes are sometimes linked to specific disease presentations.
Purpose of the Study:
- To investigate novel saccadic paradigms in behavioral variant frontotemporal dementia (bvFTD).
Main Methods:
- Evaluated prosaccade, predictive, self-paced, memory-guided, and anti-saccade tasks.
- Compared performance between bvFTD patients and healthy controls.
Main Results:
- bvFTD patients exhibited significantly increased saccadic latency across all tested tasks.
- Reduced self-paced saccade numbers and increased errors in memory-guided saccades were observed.
- While predictive saccade latency increased, this effect diminished when accounting for prosaccade latency changes.
Conclusions:
- bvFTD patients demonstrate widespread saccadic testing alterations.
- These saccadic changes likely correlate with the known frontal lobe pathology in bvFTD.
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