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Updated: Feb 7, 2026

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii

Published on: June 22, 2017

Toxoplasma gondii.

Joshua A Kochanowsky¹, Anita A Koshy²

¹Department of Immunobiology, University of Arizona, Tucson, AZ 85721, USA.

Current Biology : CB

|July 25, 2018

Summary

Toxoplasma gondii, a parasite common in cats, may influence host behavior. This review examines the scientific evidence for its effects on brain function and whether these changes are intentional.

Area of Science:

Parasitology
Neuroscience
Behavioral Science

Background:

Toxoplasma gondii is an obligate intracellular parasite with a complex life cycle.
Infection is widespread in humans and other warm-blooded animals.
Previous research suggests T. gondii may alter host behavior.

Purpose of the Study:

To review the current scientific literature on Toxoplasma gondii and its potential effects on host brain function.
To critically evaluate the evidence for behavioral manipulation by the parasite.
To discuss the implications of T. gondii infection for human and animal health.

Main Methods:

Literature review of peer-reviewed studies.
Analysis of experimental data on parasite-host interactions.

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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

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Published on: December 9, 2014

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3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii

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Synthesis of findings from parasitological, neurological, and behavioral studies.

Main Results:

Evidence suggests T. gondii infection can alter neurotransmitter levels and brain activity in rodents.
Observed behavioral changes in infected rodents include altered fear responses and increased risk-taking.
Human studies show correlations between T. gondii infection and changes in personality and mental health, but causality is not established.

Conclusions:

T. gondii exhibits the capacity to modify host behavior, particularly in rodents.
The extent and mechanisms of behavioral manipulation in humans require further investigation.
Understanding T. gondii's impact on the brain is crucial for public health and disease management.