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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
Published on: October 6, 2023
Muscle, a conduit to brain for hormonal control of behavior
Barney A Schlinger1, Ketema Paul2, D Ashley Monks3
1Department of Integrative Biology and Physiology, University of California, Los Angeles, United States of America; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, United States of America; Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, United States of America; Smithsonian Tropical Research Institute, Panama City, Panama.
Abstract:
SBN Elsevier Lecture Investigation into mechanisms whereby hormones control behavior often starts with actions on central nervous system (CNS) motivation and motor systems and is followed by assessment of CNS drive of coordinated striated muscle contractions. Here we turn this perspective on its head by discussing ways in which hormones might first act on muscle that then secondarily drive upstream the evolution and function of the CNS. While there is a lengthy history for consideration of this perspective, newly discovered properties of muscle signaling reveal novel mechanisms that may well be captured by endocrine systems and thus of interest to behavioral endocrinologists.
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