Related Experiment Video
Updated: Feb 7, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
Identification of a novel tri-genotypic recombinant Hepatitis B virus in Bangladesh
Modhusudon Shaha1, Md Hadisur Rahman2, Munira Jahan3
1Microbial Biotechnology Division, National Institute of Biotechnology, Savar, Dhaka, 1349, Bangladesh.
Abstract:
We report a novel tri-genotypic recombinant Hepatitis B virus (HBV) strain circulating in Bangladesh. The strain is recombinant with the genotypes D, C and E, of which, genotype E was not reported before in Bangladesh. Additionally, the complete genome has a frameshift deletion of nine nucleotides from overlapping Surface and Polymerase genes, and a vaccine escape mutation, A128 V, in the surface protein. This is the first report with such unusual recombination event responsible for rapid liver cirrhosis in a 13 year old patient in Bangladesh. This report may alert the clinicians to take the measure to prevent an upcoming outbreak of recombinant HBV.
Related Concept Videos
Viral Recombination
Recombinant DNA
What are Viruses?
Homologous Recombination
Overview of Transposition and Recombination
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

