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C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health

Silvia Arboleya1,2, M Suárez3, N Fernández2,3

  • 1Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias (IPLA-CSIC), Villaviciosa, Spain.

Annals of Nutrition & Metabolism
|July 25, 2018
PubMed

Insights

Caesarean delivery (CS) significantly impacts infant gut microbiome development, altering microbial diversity. This review explores CS effects and strategies to restore the infant gut microbiome for long-term health.

Area of Science:

  • Microbiology
  • Pediatrics
  • Obstetrics

Background:

  • Human gut microbiota assembly during infancy is crucial for health.
  • Caesarean delivery (CS) disrupts optimal microbial colonization.
  • Rising CS rates worldwide exceed WHO recommendations.

Purpose of the Study:

  • Review clinical parameters for appropriate CS recommendations.
  • Discuss CS impact on infant gut microbiome acquisition and long-term health.
  • Analyze strategies for gut microbiota restoration post-CS.

Main Methods:

  • Literature review of clinical parameters and microbiome studies related to CS.
  • Analysis of microbial changes in infants following different delivery modes.
  • Evaluation of strategies for mitigating CS effects on the microbiome.

Main Results:

  • CS delivery alters the infant gut microbiome composition and diversity.
  • Medical practices surrounding CS further influence microbial acquisition.
  • Both early and long-lasting health effects are observed in mother and infant dyads.

Conclusions:

  • CS delivery necessitates careful clinical consideration due to microbiome disruption.
  • Strategies are needed to minimize the negative impact of CS on infant microbiome development.
  • Future research should focus on microbiome restoration to promote infant health.
Abstract

Keywords:
C-sectionDelivery modeGutHealthInfantMicrobiotaRestoration strategies

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