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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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External Anatomy of the Kidney01:21

External Anatomy of the Kidney

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The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
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Updated: Jan 28, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Apheresis for Kidney Disease.

Kengo Furuichi, Takashi Wada

    Contributions to Nephrology
    |July 25, 2018
    PubMed
    Summary

    Apheresis therapies like plasma exchange and LDL apheresis are valuable for kidney diseases such as rapidly progressive glomerulonephritis and lupus nephritis. Further research is needed to fully establish their effectiveness and potential in nephrology.

    Area of Science:

    • Nephrology
    • Immunology
    • Therapeutic Apheresis

    Background:

    • Apheresis therapies are crucial in managing various kidney diseases.
    • Established treatments include plasma exchange and low-density lipoprotein (LDL) apheresis for specific glomerulonephritis types.

    Purpose of the Study:

    • To review the current clinical applications and potential of apheresis in kidney diseases.
    • To explore the underlying mechanisms and future directions for apheresis in nephrology.

    Main Methods:

    • Literature review of apheresis therapies in kidney diseases.
    • Analysis of clinical studies and animal experiments.
    • Discussion of established and potential applications.

    Main Results:

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    • Plasma exchange and LDL apheresis are clinically valuable for conditions like rapidly progressive glomerulonephritis, lupus nephritis, and focal segmental glomerulonephritis.
    • While some applications are limited, apheresis shows suggestive mechanisms and great potential for kidney diseases.

    Conclusions:

    • Apheresis therapies, including plasma exchange and LDL apheresis, offer significant clinical value in nephrology.
    • Further investigation is required to fully elucidate the effectiveness and mechanisms of apheresis in kidney diseases.