Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

661
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
661
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

1.0K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.0K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.0K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.0K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

573
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
573
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

344
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
344
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

247
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
247

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world, multi-omics validation of the clinical relevance of molecular taxonomy for myelodysplastic syndromes (MDS).

HemaSphere·2026
Same author

Evaluation of prognostic factors and outcomes in primary versus secondary myeloid sarcoma.

Human pathology·2026
Same author

Monocytes matter: prognostic impact in clonal hematopoiesis.

Blood·2026
Same author

Deletion 11q, monosomy 13, and deletion 13q in noncomplex karyotype acute myeloid leukemia.

Blood neoplasia·2026
Same author

Contemporary approach to diagnosis and classification of acute myeloid leukemia.

Human pathology·2026
Same author

The Clinicopathologic and Genomic Features of Mature Versus Blastic Plasmacytoid Dendritic Cell Neoplasms Arising From Chronic Myeloid Neoplasms.

The American journal of surgical pathology·2026

Related Experiment Video

Updated: Feb 7, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

10.2K

Myelodysplastic Syndrome Updated.

Robert P Hasserjian

    Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
    |July 25, 2018
    PubMed
    Summary
    This summary is machine-generated.

    The 2016 WHO Classification of Myeloid Neoplasms updates the diagnosis and management of myelodysplastic syndromes (MDS). Key changes include molecular insights and refined risk stratification for tailored patient therapies.

    Keywords:
    CytogeneticsMyelodysplastic syndromeMyeloid neoplasmsRing sideroblasts

    More Related Videos

    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
    06:33

    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

    Published on: November 10, 2023

    1.9K
    Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
    08:31

    Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

    Published on: July 31, 2016

    14.5K

    Related Experiment Videos

    Last Updated: Feb 7, 2026

    Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
    06:39

    Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

    Published on: October 3, 2018

    10.2K
    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
    06:33

    Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

    Published on: November 10, 2023

    1.9K
    Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
    08:31

    Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

    Published on: July 31, 2016

    14.5K

    Area of Science:

    • Hematology
    • Oncology
    • Molecular Genetics

    Background:

    • The 2008 WHO Classification of Myeloid Neoplasms provided a framework for diagnosing myelodysplastic syndromes (MDS).
    • Advances in molecular genetics have significantly improved understanding of MDS pathogenesis since 2008.

    Purpose of the Study:

    • To review the principal modifications in the 2016 WHO Classification of Myeloid Neoplasms relevant to MDS.
    • To elucidate how these revisions impact the diagnostic and therapeutic strategies for MDS patients.

    Main Methods:

    • Review of the 2016 WHO Classification of Myeloid Neoplasms (published in 2017).
    • Analysis of new molecular genetic data influencing MDS classification.
    • Examination of revised disease categories and their implications for risk stratification.

    Main Results:

    • Reorganization of MDS disease categories based on updated data.
    • Broadened classification of MDS with ring sideroblasts, often linked to SF3B1 mutations.
    • Refined definitions for improved disease risk stratification.

    Conclusions:

    • The revised classification incorporates new molecular findings for more accurate MDS diagnosis.
    • Updated categories facilitate risk-adapted therapy, optimizing patient management.
    • The 2016 WHO classification enhances precision in MDS diagnosis and treatment strategies.