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Related Experiment Video

Updated: Feb 7, 2026

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Published on: August 25, 2019

Zebrafish as a Model to Evaluate Nanoparticle Toxicity.

Enamul Haque^1,2, Alister C Ward^3,4

¹School of Medicine, Deakin University, Waurn Ponds, VIC 3216, Australia. md.haque@deakin.edu.au.

Nanomaterials (Basel, Switzerland)

|July 26, 2018

Summary

Zebrafish models effectively assess nanoparticle toxicity for clinical and environmental safety. This review details how zebrafish evaluate nanoparticle biocompatibility and potential health risks.

Keywords:

biocompatibility nanoparticles nanotoxicity zebrafish

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Last Updated: Feb 7, 2026

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

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Published on: August 25, 2019

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Kupffer Cell Isolation for Nanoparticle Toxicity Testing

Kupffer Cell Isolation for Nanoparticle Toxicity Testing

Published on: August 18, 2015

Area of Science:

Biomedical Engineering
Environmental Toxicology
Nanotechnology

Background:

Nanoparticles offer significant potential in medicine (drug delivery, diagnostics) and industry, but their environmental exposure necessitates safety assessments.
Understanding nanoparticle interactions with biological systems is crucial for evaluating both clinical safety and environmental impact.
Zebrafish are emerging as a valuable model organism for comprehensive nanoparticle biocompatibility and toxicity studies.

Purpose of the Study:

To review the utility of zebrafish as a model for assessing nanoparticle toxicity.
To outline the various levels at which zebrafish can be used to evaluate nanoparticle effects.
To provide an overview of existing studies on metal, metal oxide, and carbon-based nanoparticle toxicity in zebrafish.

Main Methods:

Utilizing zebrafish to assess nanoparticle toxicity across multiple endpoints.
Evaluating mortality, teratogenicity, immunotoxicity, and genotoxicity.
Monitoring physiological readouts including reproduction and behavior.

Main Results:

Zebrafish models allow for multi-level assessment of nanoparticle toxicity.
Studies have demonstrated the utility of zebrafish in evaluating various nanoparticle types (metal, metal oxide, carbon-based).
Diverse toxicological endpoints can be effectively measured in zebrafish exposed to nanoparticles.

Conclusions:

Zebrafish provide a robust and versatile model for in vivo nanoparticle safety evaluation.
This model aids in understanding nanoparticle interactions and potential health implications.
Findings inform the development of safer, biocompatible nanoparticles for diverse applications.