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Related Experiment Videos

Heparin-induced coagulopathy.

W R Bell, N D Anderson, A O Anderson

    The Journal of Laboratory and Clinical Medicine
    |April 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    High-dose intravenous heparin in rats caused intravascular coagulopathy, leading to intestinal bleeding and altered coagulation factors. This effect was dose-dependent and not caused by conventional heparin doses or protamine sulfate neutralization.

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    Area of Science:

    • Pharmacology
    • Hematology
    • Toxicology

    Background:

    • Intravenous heparin is a widely used anticoagulant.
    • High doses of heparin may have uncharacterized effects on coagulation.
    • Understanding heparin's complex interactions is crucial for clinical safety.

    Purpose of the Study:

    • To investigate the effects of high-dose intravenous heparin on coagulation in rats.
    • To characterize the specific coagulopathy induced by high-dose heparin.
    • To differentiate this coagulopathy from effects of conventional heparin doses or other agents.

    Main Methods:

    • Rats were administered intravenous heparin at 3.0 U./gm body weight.
    • Coagulation parameters including plasma fibrinogen, fibrinogen-fibrin degradation products, and platelet counts were measured.

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  • Control groups received conventional heparin doses or heparin with protamine sulfate.
  • Exclusion studies assessed hypoxemia, acidosis, and endotoxemia.

    • Main Results:

    • High-dose heparin induced an intravascular coagulopathy characterized by intestinal hemorrhage.
    • Significant reduction in plasma fibrinogen and a rise in fibrinogen-fibrin degradation products were observed.
    • Platelet counts did not increase as seen in control animals.
    • The coagulopathy was not replicated with conventional heparin doses or heparin neutralized by protamine sulfate.

    Conclusions:

    • High-dose intravenous heparin, but not conventional doses, induces a specific coagulopathy in rats.
    • The observed coagulopathy involves intestinal bleeding and altered fibrinogen metabolism.
    • The precise pathogenesis remains uncertain, but hypoxemia, acidosis, and endotoxemia were excluded as causes.