Effects of Photo-Activated Nanomicelles Loaded with Fragrance on Central Nervous System

Many kinds of fragrances have the effects on life cultivation and health preservation. These fragrances can be used for emotional regulation, partly because of the way it can modulate our central nervous system (CNS), further affect our moods and even improve our behaviour. But the effects are very dependent on their concentrations in the air. In this study, photo-responsive micelles named as PPMM-PEG@S803 were designed and prepared to encapsulate and controllably release sandela 803. PPMM-PEG@S803 was then applied to wallpaper (PPMM-PEG-W@S803) and the effects of this treated wallpaper on CNS of mice were evaluated. The results showed that PPMM-PEG-W@S803 had excellent decompression effects and antianxiety effects. And the mechanisms of these effects maybe lie in the increases of neural activity in hippocampus, hypothalamus and olfactory bulb regions, the enhances of the abilities of nerve regeneration in olfactory bulb, corpus striatum and substantia nigra and the increases of the expressions of dopamine, acetylcholine, γ-aminobutyric acid and N-methyl-D-aspartic acid. Besides, the effects were more significant as time progresses.