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Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis
Published on: June 26, 2016
Vitamin D: And its role in breast cancer
Miriam de La Puente-Yagüe1, Maria A Cuadrado-Cenzual2, María J Ciudad-Cabañas3
1Obstetrics and Gynecology, Hospital Clínico Universitario, San Carlos, Madrid, Spain.
Abstract:
Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti-inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis. The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment. A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer.
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