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Related Experiment Video

Updated: Feb 7, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Pathogen inactivation/reduction technologies for platelet transfusion: Where do we stand?

O Garraud1, M Lozano2

  • 1EA3064, Faculty of medicine of Saint-Etienne, University of Lyon, 42023 Saint-Etienne, France; Institut national de la transfusion sanguine, 75015 Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|July 26, 2018
PubMed
Summary

Pathogen inactivation technologies enhance platelet safety by reducing microbial, viral, and protozoa infections. While generally safe, potential risks include increased demand and alloimmunization with aged platelets.

Keywords:
Concentrés plaquettairesHemovigilanceHémovigilanceInactivation des pathogènesPathogen inactivationPathogen reduction technologyPlatelet componentPlatelet transfusionProcédés de réduction des pathogènesTransfusion de plaquettes

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Area of Science:

  • Blood Component Safety
  • Transfusion Medicine
  • Microbiology

Background:

  • Transfusion-transmitted bacterial infections remain a risk despite safety measures.
  • Pathogen inactivation technologies (PIT) aim to improve the microbial safety of platelet components.
  • Existing methods have reduced but not eliminated transfusion-transmitted infections.

Purpose of the Study:

  • To critically review pathogen inactivation or reduction technologies for platelet components.
  • To discuss the benefits and potential drawbacks of these technologies.
  • To present the main features and implementation of available processes.

Main Methods:

  • Review of available literature on pathogen inactivation technologies for platelets.
  • Analysis of the mechanisms of action, including nucleic acid targeting.
  • Discussion of clinical evaluation and industry-implemented processes.

Main Results:

  • PIT reduces microbial, viral, and protozoa infections, and may alleviate Transfusion Associated Graft versus Host Disease risk.
  • Potential detrimental effects include platelet damage additive to storage lesions.
  • Debated consequences include increased platelet demand and alloimmunization risk with aged platelets.

Conclusions:

  • Pathogen inactivation technologies offer significant safety benefits for platelet components.
  • Careful consideration of potential risks, such as alloimmunization, is necessary.
  • Ongoing evaluation and implementation of these technologies are crucial for transfusion safety.