Related Experiment Video
Updated: Feb 7, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
25.0K
Epidermal Nevi and Related Syndromes - Part 2: Nevi Derived from Adnexal Structures
J Garcias-Ladaria1, M Cuadrado Rosón2, M Pascual-López1
1Servicio de Dermatología, Hospital de Manacor, Manacor, Islas Baleares, España.
Actas Dermo-Sifiliograficas
|July 26, 2018
Summary
This review explores epidermal nevi, focusing on adnexal nevi and their associated syndromes. Advances in genetics enhance understanding of these skin lesions and their systemic connections.
Area of Science:
- Dermatology
- Genetics
- Pathology
Background:
- Epidermal nevi are complex hamartomatous skin lesions originating from epidermal and adnexal structures.
- Traditional classification relies on morphology, but recent advances reveal new variants.
- Genetic insights are crucial for understanding epidermal nevi and their extracutaneous associations.
Purpose of the Study:
- To review epidermal nevi derived from skin adnexal structures.
- To discuss syndromes associated with these adnexal nevi.
- To provide an updated understanding of epidermal nevi based on recent genetic findings.
Main Methods:
- Literature review of recent studies on epidermal nevi.
- Analysis of genetic advancements in characterizing skin lesions.
- Synthesis of information on adnexal nevi and associated syndromes.
Main Results:
- Adnexal nevi represent a distinct category of epidermal nevi.
- Specific genetic mutations correlate with certain adnexal nevi and syndromes.
- Understanding these associations is key for diagnosis and management.
Conclusions:
- Adnexal nevi require specific consideration due to their unique origins and potential syndromic links.
- Genetic analysis is pivotal for accurate diagnosis and classification of epidermal nevi.
- Further research into adnexal nevi and associated syndromes will improve patient outcomes.
Keywords:
Becker nevusFollicular nevusGenes RASNevus de BeckerNevus folicularesNevus ostial anexial poroqueratósicoNevus sebáceoPorokeratotic adnexal ostial nevusRAS genesRASopathyRasopatíaSchimmelpenning syndromeSebaceous nevusSiringocistoadenoma papilíferoSyringocystadenoma papilliferumSíndrome de Schimmelpenning
Related Concept Videos
01:28Structures of Carboxylic Acid Derivatives
3.8K
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
3.8K
01:35Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
2.6K
Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
2.6K
01:12Renewal of Skin Epidermal Stem Cells
3.1K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.1K
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:24Nephrotic Syndrome I : Introduction
661
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
661
01:30Acute Coronary Syndrome I: Introduction
1.0K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.0K